Mechanistic studies in renal, vascular and phagocytic cells exposed to cytokines and high-glucose showed that SOCS1 blocked ROS generation by inhibiting both Nox complex assembly and Nox subunit expression, an effect mediated by inactivation of JAK2, STAT1, and PI3K signaling pathways. Oxidative stress resulting from excessive production of reactive oxygen species (ROS) or impaired antioxidant.. Inflammation has emerged as a key pathophysiology mechanism with important implications from a therapeutic perspective. Diabetes mellitus (DM) is one of the most significant health problems worldwide. According to the projections, the number of adult diabetic patients will be higher than 430 million in 2030. Diabetic kidney disease (DKD) is one.
SOCS1targeted therapy ameliorates renal and vascular oxidative stress in diabetes via STAT1 and
La diabetes y su relación con la enfermedad renal Médica Santa Carmen
Diabetic Nephropathy Stages, Symptoms, Causes & Treatment
A mutual regulatory loop between miR155 and SOCS1 influences renal inflammation and diabetic
SOCS1targeted therapy ameliorates renal and vascular oxidative stress in diabetes via STAT1 and
SOCS1 peptide protects from diabetesassociated renal injury in... Download Scientific Diagram
Molecular mechanisms and therapeutic targets for diabetic kidney disease Kidney International
A mutual regulatory loop between miR155 and SOCS1 influences renal inflammation and diabetic
Terapia Renal Substitutiva de Antônio Vanderlei Dos Santos, Jane Conceição Perin Lucca e Rosane
SOCS1targeted therapy ameliorates renal and vascular oxidative stress in diabetes via STAT1 and
Conventional pathophysiology of diabetes kidney disease. Diabetic... Download Scientific Diagram
A stepwise approach to guide kidney biopsy in diabetic patients. NDRD,... Download Scientific
Terapia de reemplazo renal en lesión renal aguda Medical & Gabeents
Diabetic Nephropathy Symptoms, Causes, Diagnosis and treatment
Afectación renal en la diabetes mellitus
Diabetic Kidney Disease and the Cardiorenal Syndrome Endocrinology and Metabolism Clinics
(PDF) RNF7 inhibits apoptosis and sunitinib sensitivity and promotes glycolysis in renal cell
Therapeutic Advances in Kidney Failure Care Linked to Improved Survival Renal and Urology News
Diabetes e insuficiencia renal Todo lo que debes saber Alai
SOCS1targeted therapy ameliorates renal and vascular oxidative stress in diabetes via STAT1 and
Gomez-Guerrero and colleagues report that miR-155-5p promotes renal damage through targeting SOCS1, leading to JAK/STAT activation, cytokine expression, and cell proliferation and migration. In diabetic mice, both miR-155-5p inhibition and SOCS1 overexpression attenuate kidney damage, inflammation, and fibrosis, thus supporting the therapeutic potential of the miR-155/SOCS1 axis in human.. Original Article A mutual regulatory loop between miR-155 and SOCS1 influences renal inflammation and diabetic kidney disease Ignacio Prieto, 1,2 María Kavanagh, Luna Jimenez-Castilla, 1,2 Marisa Pardines, Iolanda Lazaro,3 Isabel Herrero del Real,1 Monica Flores-Muñoz, 4Jesus Egido,1,2 Oscar Lopez-Franco, and Carmen Gomez-Guerrero1,2 1Renal, Vascular and Diabetes Research Lab, Instituto de.
